Molecular and Cell Biology

Creating vaccines to train the immune system against parasites is particularly challenging. They are also highly specialized masters of immune evasion.

Some parasites can secrete proteins that bind to immune cell molecules, manipulating them for their survival purposes. Some have complex and fast life cycles so by the time the immune system has learned to recognize one form, it has already shifted to another.

Professor Xuecai Ge, a developmental neurobiologist, has received a CAREER award for research to gain insight into the molecular mechanisms that direct brain formation, and how errors in cell signaling lead to developmental disorders.

Ge is the 31st number researcher from UC Merced to earn a CAREER award from the National Science Foundation (NSF).

As a young child, Professor Michele Nishiguchi would dive off the couch and into the shag carpet reefs of her family home, mimicking the turns and leaps of intrepid explorer and environmentalist Jacques Cousteau. This love of the ocean would remain with Nishiguchi as she progressed through her academic career.

An HIV-inhibiting silk film designed to advance prevention and help end the AIDS epidemic in countries in Africa, developed by UC Merced Professor Patti LiWang, has met recent success at the California National Primate Research Center at UC Davis.

“They show complete protection,” LiWang said. “The films worked perfectly on the macaques at Davis.”

Cartilaginous fishes such as sharks and skates have a sixth sense, but it’s not ESP — it’s electrosense. Such fishes use hundreds or thousands of specialized organs to sense prey and mates and to navigate the oceans.

A cross-disciplinary group of researchers at UC Merced is making new discoveries about the fundamental structure of the organs and how this structure may provide clues as to how this sixth sense works.

A group of researchers harnessing the power of light to control gene expression has dramatically improved its method, optimizing speed and precision, and opening new research avenues for scientists who employ optogenetics — the use of light and genetic engineering to control cells.

A new paper in the journal Zebrafish details the advancements made in Professor Stephanie Woo’s lab and quantifies the results of experiments on zebrafish embryos.

A half-dozen UC Merced students and alumni are recipients of significant fellowships to help support their graduate education.

“We’re extremely proud of our undergraduate and graduate students and alumni who have earned prestigious fellowships,” Vice Provost and Graduate Dean Chris Kello said. “These awards will allow scholars to embark on or continue their graduate-level research opportunities.”

(Select the link below to learn more about the recipients.)

Immunology Professor Jennifer Manilay and bioengineering Professor Joel Spencer are using a new grant from the National Institutes of Health (NIH) to expand a project they’ve been working on for the past two years — delving into the immune systems of living mice to see how B-cells develop under different circumstances.

From graduate student Jose Zamora’s perspective, the CREST Center for Cellular and Biomolecular Machines (CCBM) has been a spectacular success.

A brand-new faculty member is shaking up the way researchers understand cellular systems.

Computational biology Professor Bercem Dutagaci, who started at UC Merced in January, developed simulations of bacterial cells as a new way of looking at how RNA and proteins self-organize inside the cells. Her most recent work demonstrates that the insides of cells are organized at complex levels of order, instead of a chaotic stew of molecules.