Marcos García-Ojeda

[faculty_first_name] [faculty_last_name]
Lecturer with Potential Security of Employment
School of Natural Sciences
Office
Phone 
209-228-6986
Location 
S&E 1 Bldg., RM 326
Lab
Location 
S&E 1 Bldg., RM 325
Research Interests 

Stem cells give rise to and maintain many tissues. During its life, a stem cell can follow one of three fates:

  1. Self renew, preserving a constant pool of stem cells in the tissue
  2. Differentiate into another cell type
  3. Die

Signals from the environment — either from other cells or soluble factors — can activate a genetic program within the stem cell, inducing its differentiation into a particular cell type. The activation of a genetic program is mirrored by the silencing of other alternative genetic programs. In this way, the stem cell reaches a point where it is irreversibly committed to a particular cell fate.

Using the hematopoetic (bone marrow) stem cell as a model, Professor Garcia-Ojeda's lab studies the microenvironmental and genetic signals required for stem cell function and lymphocyte development. In particular, he is interested in the role of the transcription factor GATA-3 in the commitment and differentiation of stem cells into T cells.

Education 
  • Ph.D., 2002 — Stanford University
  • M.A., 1992 — University of California, Santa Cruz
  • B.S., 1990 — University of Illinois, Urbana-Champaign