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Jinah Choi

Jinah  Choi
Title: 
Associate Professor
Phone: 
(209) 228-4386
Office: 
S&E 1 Bldg., RM 248
Location: 
S&E 1 Bldg., RM 253
Education: 
  • Ph. D., 1999 — University of Southern California
  • B.S., 1992 — University of California, Los Angeles
Research Interests: 
  • Understanding the role of oxidative stress in viral infections
  • Interaction of ethanol and hepatitis C virus (HCV)
  • Mechanisms of chemical-biological and virus-host interactions to identify novel targets for therapy
  • Mechanism and function of alternate frames decoding during HCV infection

Recent findings from Professor Choi's laboratory suggest that:

  • HCV induces oxidative stress by specific modulation of host gene expression
  • This perburbation of the host redox status has significant effects on HCV genome and its replication
  • Increased oxidative stress is likely to promote the development and progression of severe liver diseases, including hepatocellular carcinoma
  • Ethanol, an important cofactor in liver diseases, elevates complete replication of HCV at physiologically relevant doses
  • F protein (also known as ARFP, Core+1/F, and p17) has important biological functions during HCV infection

Profess Choi has studies in progress to define the underlying mechanisms as well as in vivo relevance of these findings.